Secondary acute myeloid leukaemia: results of conventional treatments. Experience of GIMEMA trials

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Secondary acute myeloid leukaemia: results of conventional treatments. Experience of GIMEMA trials.

BACKGROUND The aim of the study was to evaluate the outcome of acute myeloid leukaemia (AML) in patients with a previous malignancy (sAML) treated with chemo- and/or radiotherapy, enrolled in conventional trials. PATIENTS AND METHODS In a multicentre setting, a prospective non-concurrent analysis was performed on 2513 new AML patients, aged 12-78 years, consecutively enrolled in EORTC-GIMEMA ...

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Original article Secondary acute myeloid leukaemia: results of conventional treatments. Experience of GIMEMA trials

Cattedra di Ematologia, Università Cattolica S. Cuore, Rome; Dipartimento di Biotecnologie cellulari ed Ematologia, Università “La Sapienza”, Rome; Centro Dati GIMEMA Dipartimento di Biotecnologie cellulari ed Ematologia, Università “La Sapienza”, Rome; Dipartimento di Epidemiologia e Biostatistica Istituto Superiore di Sanità, Rome; U.O.A. di Ematologia, Ospedale SS: Antonio e Biagio, Alessand...

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The Effect of Monophosphoryl Lipid A on Maturation of DCs from Patients with Acute Myeloid Leukaemia

Background: Generation of monocyte-derived dendritic cells (MDDC) is induced in the presence of GM-CSF and IL-4, and a maturation stimulus is added to the monocyte culture to obtain mature Dendritic Cells (DCs) suitable for therapy. TNF-α is the most common cytokine used for activating DCs and generating mature MDDC either alone or in combination with other cytokines. Objective: To compare effe...

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Glutathione S-transferases Null Genotype in Acute Myeloid Leukaemia

Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated with several malignancies. Objective: To investigate the rate of GSTT1 and GSTM1 null ge...

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Diagnosis of Acute Myeloid Leukaemia

Acute myeloid leukaemia (AML) is a clonal, malignant disease of hematopoietic tissue characterized by accumulation of abnormal cells, mainly leukaemic blasts in bone marrow and impaired production of normal hematopoietic cells. Leukaemia was discovered in 1845, roughly at the same time by two doctors, Rudolph Virchow, a young Berlin pathologist and a Scottish pathologist, John Hughes Bennett. T...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 2005

ISSN: 0923-7534

DOI: 10.1093/annonc/mdi051